Tlr2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tlr2
toll-like receptor 2
MGI:1346060

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0001540	amyloid-beta binding	IDA	J:180762
Molecular Function	GO:0042498	diacyl lipopeptide binding	IDA	J:158053
Molecular Function	GO:0042498	diacyl lipopeptide binding	IDA	J:156189
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0071723	lipopeptide binding	ISO	J:155856
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0070891	lipoteichoic acid binding	IDA	J:156189
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0042834	peptidoglycan binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:169893
Molecular Function	GO:0005515	protein binding	IPI	J:110094
Molecular Function	GO:0005515	protein binding	IPI	J:266414
Molecular Function	GO:0005515	protein binding	IPI	J:248448
Molecular Function	GO:0005515	protein binding	IPI	J:156189
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:180762
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0035325	Toll-like receptor binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0042497	triacyl lipopeptide binding	IBA	J:265628
Molecular Function	GO:0042497	triacyl lipopeptide binding	ISO	J:158053
Molecular Function	GO:0042497	triacyl lipopeptide binding	IDA	J:158053
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:91804
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:89998
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	ISO	J:164563
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	ISO	J:158053
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	ISO	J:164563
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex	IPI	J:156189
Biological Process	GO:0002752	cell surface pattern recognition receptor signaling pathway	IMP	J:89998
Biological Process	GO:0071221	cellular response to bacterial lipopeptide	TAS	J:161025
Biological Process	GO:0071221	cellular response to bacterial lipopeptide	IMP	J:96018
Biological Process	GO:0071726	cellular response to diacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0071223	cellular response to lipoteichoic acid	IMP	J:96018
Biological Process	GO:0071223	cellular response to lipoteichoic acid	ISO	J:73065
Biological Process	GO:0071224	cellular response to peptidoglycan	IMP	J:113450
Biological Process	GO:0071727	cellular response to triacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0032289	central nervous system myelin formation	ISO	J:155856
Biological Process	GO:0032602	chemokine production	IMP	J:104231
Biological Process	GO:0006952	defense response	IMP	J:95726
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:96018
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:147177
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:106736
Biological Process	GO:0042496	detection of diacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0042495	detection of triacyl bacterial lipopeptide	ISO	J:73065
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:178691
Biological Process	GO:0007252	I-kappaB phosphorylation	ISO	J:164563
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	TAS	J:161025
Biological Process	GO:0032620	interleukin-17 production	IMP	J:104231
Biological Process	GO:0032635	interleukin-6 production	IDA	J:132126
Biological Process	GO:0032635	interleukin-6 production	IMP	J:106736
Biological Process	GO:0032635	interleukin-6 production	IMP	J:76115
Biological Process	GO:0007612	learning	IGI	J:180762
Biological Process	GO:0050900	leukocyte migration	IMP	J:140680
Biological Process	GO:0006691	leukotriene metabolic process	ISO	J:155856
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:96018
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:106736
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:76115
Biological Process	GO:0014005	microglia development	IGI	J:180762
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IGI	J:89998
Biological Process	GO:0030837	negative regulation of actin filament polymerization	IGI	J:180762
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:113450
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:104231
Biological Process	GO:0050765	negative regulation of phagocytosis	IMP	J:180762
Biological Process	GO:0050765	negative regulation of phagocytosis	IGI	J:180762
Biological Process	GO:0051964	negative regulation of synapse assembly	IGI	J:180762
Biological Process	GO:1990266	neutrophil migration	IMP	J:140680
Biological Process	GO:0038061	NIK/NF-kappaB signaling	IMP	J:178691
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:104231
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:76115
Biological Process	GO:0046209	nitric oxide metabolic process	ISO	J:155856
Biological Process	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:104231
Biological Process	GO:0001819	positive regulation of cytokine production	IGI	J:153503
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:178691
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:180762
Biological Process	GO:0032728	positive regulation of interferon-beta production	IDA	J:161025
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:180762
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:155856
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:161025
Biological Process	GO:0032741	positive regulation of interleukin-18 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:132126
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:106736
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:76115
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0002687	positive regulation of leukocyte migration	IMP	J:140680
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:106736
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:96018
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:76115
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:76115
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:106736
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:76115
Biological Process	GO:1904466	positive regulation of matrix metallopeptidase secretion	ISO	J:164563
Biological Process	GO:1902624	positive regulation of neutrophil migration	IMP	J:140680
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:73065
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:178691
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:76115
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:104231
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	J:161025
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:161025
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:180762
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:180762
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:180762
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:161025
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:96018
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:89998
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:104231
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:76115
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:106736
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:1904417	positive regulation of xenophagy	IMP	J:178691
Biological Process	GO:0001817	regulation of cytokine production	IEA	J:72247
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	IDA	J:143745
Biological Process	GO:0032493	response to bacterial lipoprotein	ISO	J:155856
Biological Process	GO:0009617	response to bacterium	IMP	J:140680
Biological Process	GO:0070542	response to fatty acid	ISO	J:155856
Biological Process	GO:0002237	response to molecule of bacterial origin	IEA	J:72247
Biological Process	GO:0002238	response to molecule of fungal origin	IMP	J:89998
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:140680
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:76115
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628
Biological Process	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	ISO	J:164563
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:106736
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:104231
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:76115
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:96018
Biological Process	GO:0098792	xenophagy	IMP	J:178691

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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