GO Annotations Graph

• Symbol: Gdf15
• Name: growth differentiation factor 15
• ID: MGI:1346047

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:283184
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IDA	J:261053
Cellular Component	GO:0005576	extracellular region	IDA	J:283184
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060400	negative regulation of growth hormone receptor signaling pathway	IDA	J:261053
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IDA	J:261053
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:254140
Biological Process	GO:1901741	positive regulation of myoblast fusion	IMP	J:204300
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	ISO	J:164563
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	IDA	J:283184
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	IMP	J:197174
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	IDA	J:251855
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628