Slc11a1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015086	cadmium ion transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	IMP	J:111818
Molecular Function	GO:0051139	metal cation:proton antiporter activity	ISO	J:164563
Molecular Function	GO:0051139	metal cation:proton antiporter activity	IBA	J:265628
Molecular Function	GO:0046873	metal ion transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0046915	transition metal ion transmembrane transporter activity	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	IDA	J:38944
Cellular Component	GO:0005770	late endosome	IMP	J:38944
Cellular Component	GO:0005770	late endosome	IDA	J:125286
Cellular Component	GO:0005764	lysosome	IDA	J:125286
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030670	phagocytic vesicle membrane	ISO	J:164563
Cellular Component	GO:0030670	phagocytic vesicle membrane	IBA	J:265628
Cellular Component	GO:0030670	phagocytic vesicle membrane	IDA	J:38944
Cellular Component	GO:0030670	phagocytic vesicle membrane	IDA	J:42525
Cellular Component	GO:0030670	phagocytic vesicle membrane	IMP	J:111818
Cellular Component	GO:0030670	phagocytic vesicle membrane	IDA	J:111818
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0070821	tertiary granule membrane	ISO	J:164563
Biological Process	GO:0032147	activation of protein kinase activity	IMP	J:16583
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	IMP	J:125286
Biological Process	GO:0070574	cadmium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0098849	cellular detoxification of cadmium ion	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IMP	J:134454
Biological Process	GO:0042742	defense response to bacterium	IMP	J:12675
Biological Process	GO:0042742	defense response to bacterium	IMP	J:134454
Biological Process	GO:0042742	defense response to bacterium	IMP	J:6208
Biological Process	GO:0042742	defense response to bacterium	IMP	J:28278
Biological Process	GO:0042742	defense response to bacterium	IMP	J:131331
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:7248
Biological Process	GO:0042832	defense response to protozoan	IMP	J:5928
Biological Process	GO:0042832	defense response to protozoan	IMP	J:19600
Biological Process	GO:0042832	defense response to protozoan	IMP	J:29046
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:111818
Biological Process	GO:0006954	inflammatory response	IMP	J:146917
Biological Process	GO:0032623	interleukin-2 production	IMP	J:39456
Biological Process	GO:0032632	interleukin-3 production	IMP	J:39456
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	IBA	J:265628
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:139408
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:75932
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:147563
Biological Process	GO:0006826	iron ion transport	ISO	J:164563
Biological Process	GO:1903826	L-arginine transmembrane transport	IDA	J:25894
Biological Process	GO:0042116	macrophage activation	IMP	J:146917
Biological Process	GO:0042116	macrophage activation	IDA	J:25894
Biological Process	GO:0006828	manganese ion transport	IMP	J:111818
Biological Process	GO:0000165	MAPK cascade	ISO	J:60579
Biological Process	GO:0030001	metal ion transport	IDA	J:153313
Biological Process	GO:0045342	MHC class II biosynthetic process	IMP	J:16583
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0048255	mRNA stabilization	IMP	J:37761
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:50686
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:147563
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:106841
Biological Process	GO:0015707	nitrite transport	IDA	J:25894
Biological Process	GO:0006909	phagocytosis	IMP	J:131331
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:12675
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	IMP	J:146983
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:106841
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:146983
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:139408
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IMP	J:146983
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:125286
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:146983
Biological Process	GO:0045730	respiratory burst	IDA	J:25894
Biological Process	GO:0009617	response to bacterium	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IMP	J:4762
Biological Process	GO:0032496	response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:125286
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:42238
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:146983
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:60579
Biological Process	GO:0034341	response to type II interferon	IDA	J:42238
Biological Process	GO:0002369	T cell cytokine production	IMP	J:146917
Biological Process	GO:0002309	T cell proliferation involved in immune response	IMP	J:39456
Biological Process	GO:0032609	type II interferon production	IMP	J:146983
Biological Process	GO:0007035	vacuolar acidification	IMP	J:111818
Biological Process	GO:0007035	vacuolar acidification	IMP	J:115141
Biological Process	GO:0007035	vacuolar acidification	IMP	J:146983
Biological Process	GO:0042060	wound healing	IMP	J:106841

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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