GO Annotations Graph

• Symbol: Grem2
• Name: gremlin 2, DAN family BMP antagonist
• ID: MGI:1344367

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0036122	BMP binding	IMP	J:200257
Molecular Function	GO:0036122	BMP binding	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	IDA	J:205025
Molecular Function	GO:0042802	identical protein binding	IMP	J:200257
Molecular Function	GO:0042802	identical protein binding	IPI	J:205025
Molecular Function	GO:0048018	receptor ligand activity	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IMP	J:200257
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0009887	animal organ morphogenesis	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:205025
Biological Process	GO:0048263	determination of dorsal identity	IMP	J:200257
Biological Process	GO:0010172	embryonic body morphogenesis	IMP	J:205025
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:200257
Biological Process	GO:0060300	regulation of cytokine activity	IMP	J:205025
Biological Process	GO:0038098	sequestering of BMP from receptor via BMP binding	IMP	J:200257
Biological Process	GO:0038098	sequestering of BMP from receptor via BMP binding	IBA	J:265628