GO Annotations Graph

• Symbol: Kcnh2
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
• ID: MGI:1341722

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding	ISO	J:164563
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005242	inward rectifier potassium channel activity	ISO	J:155856
Molecular Function	GO:0005242	inward rectifier potassium channel activity	ISO	J:164563
Molecular Function	GO:0005242	inward rectifier potassium channel activity	IBA	J:265628
Molecular Function	GO:0005242	inward rectifier potassium channel activity	IDA	J:44554
Molecular Function	GO:0005216	monoatomic ion channel activity	ISO	J:155856
Molecular Function	GO:0005267	potassium channel activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005249	voltage-gated potassium channel activity	ISO	J:155856
Molecular Function	GO:0005249	voltage-gated potassium channel activity	ISO	J:164563
Molecular Function	GO:0005249	voltage-gated potassium channel activity	IDA	J:44553
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:1902937	inward rectifier potassium channel complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0008076	voltage-gated potassium channel complex	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0086010	membrane depolarization during action potential	ISO	J:164563
Biological Process	GO:0086009	membrane repolarization	ISO	J:164563
Biological Process	GO:0086011	membrane repolarization during action potential	ISO	J:164563
Biological Process	GO:0086011	membrane repolarization during action potential	IBA	J:265628
Biological Process	GO:0086013	membrane repolarization during cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:1903765	negative regulation of potassium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0097623	potassium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:0055075	potassium ion homeostasis	ISO	J:164563
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0071805	potassium ion transmembrane transport	IDA	J:44554
Biological Process	GO:0071805	potassium ion transmembrane transport	IDA	J:44553
Biological Process	GO:0006813	potassium ion transport	ISO	J:155856
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IBA	J:265628
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IDA	J:63073
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:73065
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:155856
Biological Process	GO:0042391	regulation of membrane potential	IDA	J:44553
Biological Process	GO:0042391	regulation of membrane potential	IDA	J:44554
Biological Process	GO:0060306	regulation of membrane repolarization	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	ISO	J:164563
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IBA	J:265628
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IDA	J:63073
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ISO	J:164563