GO Annotations Graph

• Symbol: Camk2d
• Name: calcium/calmodulin-dependent protein kinase II, delta
• ID: MGI:1341265

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISS	J:130644
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	IDA	J:326903
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:155856
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201314
Molecular Function	GO:0005515	protein binding	IPI	J:263460
Molecular Function	GO:0005515	protein binding	IPI	J:263461
Molecular Function	GO:0005515	protein binding	IPI	J:165334
Molecular Function	GO:0005515	protein binding	IPI	J:165334
Molecular Function	GO:0005515	protein binding	IPI	J:165334
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:165334
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:84257
Molecular Function	GO:0019871	sodium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0031432	titin binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:130644
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0043194	axon initial segment	IDA	J:165334
Cellular Component	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:96039
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0014704	intercalated disc	IDA	J:165334
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:128352
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	IDA	J:165334
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:96039
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:96039
Biological Process	GO:0006816	calcium ion transport	IDA	J:96039
Biological Process	GO:0006816	calcium ion transport	IMP	J:84257
Biological Process	GO:0086003	cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0086003	cardiac muscle cell contraction	ISS	J:130644
Biological Process	GO:0060048	cardiac muscle contraction	IDA	J:96039
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:84257
Biological Process	GO:0030007	intracellular potassium ion homeostasis	ISO	J:155856
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:165334
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:155856
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISS	J:130644
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:84257
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:0098901	regulation of cardiac muscle cell action potential	ISO	J:155856
Biological Process	GO:0010649	regulation of cell communication by electrical coupling	ISO	J:155856
Biological Process	GO:0060341	regulation of cellular localization	ISO	J:164563
Biological Process	GO:0003254	regulation of membrane depolarization	ISO	J:164563
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle	IGI	J:200470
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle	ISO	J:155856
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle	ISO	J:164563
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:155856
Biological Process	GO:0002028	regulation of sodium ion transport	IDA	J:165334
Biological Process	GO:0055119	relaxation of cardiac muscle	ISS	J:130644
Biological Process	GO:0055119	relaxation of cardiac muscle	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856