GO Annotations Graph

• Symbol: Fhl2
• Name: four and a half LIM domains 2
• ID: MGI:1338762

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:94194
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:94194
Molecular Function	GO:0008134	transcription factor binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0031430	M band	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:78371
Cellular Component	GO:0005634	nucleus	IDA	J:94194
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:189137
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Biological Process	GO:0055014	atrial cardiac muscle cell development	IEP	J:94194
Biological Process	GO:0060347	heart trabecula formation	IEP	J:94194
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:189137
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ISO	J:164563
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ISO	J:155856
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:94194
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0001649	osteoblast differentiation	IEP	J:143682
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:78371
Biological Process	GO:0009725	response to hormone	ISO	J:164563
Biological Process	GO:0055015	ventricular cardiac muscle cell development	IEP	J:94194