Itsn1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Itsn1
intersectin 1 (SH3 domain protein 1A)
MGI:1338069

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA	J:72247
Molecular Function	GO:0019209	kinase activator activity	IDA	J:129036
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	IBA	J:265628
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:116685
Molecular Function	GO:0005515	protein binding	IPI	J:177236
Molecular Function	GO:0005515	protein binding	IPI	J:201313
Molecular Function	GO:0005515	protein binding	IPI	J:74670
Molecular Function	GO:0005515	protein binding	IPI	J:129036
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0044305	calyx of Held	IDA	J:197322
Cellular Component	GO:0044305	calyx of Held	IDA	J:197322
Cellular Component	GO:0044305	calyx of Held	IDA	J:197322
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:227201
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928605
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928626
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928643
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:129036
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0097708	intracellular vesicle	ISO	J:155856
Cellular Component	GO:0097708	intracellular vesicle	IBA	J:265628
Cellular Component	GO:0030027	lamellipodium	IDA	J:74670
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0098833	presynaptic endocytic zone	IDA	J:197322
Cellular Component	GO:0098833	presynaptic endocytic zone	IDA	J:197322
Cellular Component	GO:0098833	presynaptic endocytic zone	IDA	J:197322
Cellular Component	GO:0042734	presynaptic membrane	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	IBA	J:265628
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0016197	endosomal transport	IBA	J:265628
Biological Process	GO:0006887	exocytosis	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:129036
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:129036
Biological Process	GO:2001288	positive regulation of caveolin-mediated endocytosis	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0060124	positive regulation of growth hormone secretion	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:129036
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0007264	small GTPase mediated signal transduction	IDA	J:74670
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:140030
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:140030
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:140030

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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