Dkk1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Dkk1
dickkopf WNT signaling pathway inhibitor 1
MGI:1329040

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0039706	co-receptor binding	ISO	J:164563
Molecular Function	GO:0039706	co-receptor binding	IBA	J:265628
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:103781
Molecular Function	GO:0005515	protein binding	IPI	J:101423
Molecular Function	GO:0005515	protein binding	IPI	J:101423
Molecular Function	GO:0048019	receptor antagonist activity	ISO	J:164563
Molecular Function	GO:0048019	receptor antagonist activity	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	ISS	J:57798
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:103781
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:134688
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:134688
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	IMP	J:134688
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:92327
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:92327
Biological Process	GO:0007492	endoderm development	IMP	J:134688
Biological Process	GO:0001706	endoderm formation	IDA	J:155850
Biological Process	GO:0060325	face morphogenesis	IMP	J:124680
Biological Process	GO:0030900	forebrain development	IGI	J:119933
Biological Process	GO:0001942	hair follicle development	IDA	J:110268
Biological Process	GO:0060323	head morphogenesis	IGI	J:134688
Biological Process	GO:0007611	learning or memory	IDA	J:241059
Biological Process	GO:0060173	limb development	IMP	J:137914
Biological Process	GO:0001707	mesoderm formation	IDA	J:155850
Biological Process	GO:0061743	motor learning	IDA	J:225337
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:240374
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:157031
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:228115
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:225337
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:239208
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:120067
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:160170
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:160170
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:73065
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:91019
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:117476
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:124891
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:134688
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:134688
Biological Process	GO:1901296	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	ISO	J:164563
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	ISO	J:164563
Biological Process	GO:0010977	negative regulation of neuron projection development	IDA	J:269539
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:155856
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:137914
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1905607	negative regulation of presynapse assembly	IDA	J:269539
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:168283
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117476
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117476
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117476
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:157031
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:124680
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:158579
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:101423
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:155850
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	ISO	J:164563
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	TAS	J:225337
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:241059
Biological Process	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	IDA	J:145669
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:1904958	positive regulation of midbrain dopaminergic neuron differentiation	IMP	J:171097
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	IDA	J:241059
Biological Process	GO:0042663	regulation of endodermal cell fate specification	ISO	J:164563
Biological Process	GO:0002090	regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0050807	regulation of synapse organization	IDA	J:225337
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IDA	J:225337
Biological Process	GO:0030111	regulation of Wnt signaling pathway	IMP	J:119933
Biological Process	GO:0032526	response to retinoic acid	IDA	J:118503
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:155850
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:158579
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:158579
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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