GO Annotations Graph

• Symbol: Sema7a
• Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
• ID: MGI:1306826

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	IPI	J:121431
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0030215	semaphorin receptor binding	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:121431
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-434991
Biological Process	GO:0048675	axon extension	IDA	J:87191
Biological Process	GO:0048675	axon extension	IMP	J:87191
Biological Process	GO:0048675	axon extension	IGI	J:87191
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0007229	integrin-mediated signaling pathway	IDA	J:121431
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	IBA	J:265628
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001755	neural crest cell migration	IBA	J:265628
Biological Process	GO:0031175	neuron projection development	IMP	J:87191
Biological Process	GO:0021988	olfactory lobe development	IMP	J:87191
Biological Process	GO:0021988	olfactory lobe development	IDA	J:87191
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:164563
Biological Process	GO:0045773	positive regulation of axon extension	IBA	J:265628
Biological Process	GO:0045773	positive regulation of axon extension	IDA	J:87191
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:121431
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:121431
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IBA	J:265628
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:87191
Biological Process	GO:0006468	protein phosphorylation	IDA	J:87191
Biological Process	GO:0050727	regulation of inflammatory response	IDA	J:121431
Biological Process	GO:0050727	regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IBA	J:265628