GO Annotations Graph

• Symbol: Apaf1
• Name: apoptotic peptidase activating factor 1
• ID: MGI:1306796

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IDA	J:62276
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:62276
Molecular Function	GO:0042802	identical protein binding	IPI	J:98949
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Cellular Component	GO:0043293	apoptosome	ISO	J:164563
Cellular Component	GO:0043293	apoptosome	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-6804642
Cellular Component	GO:0005829	cytosol	TAS	J:49840
Cellular Component	GO:0005829	cytosol	IDA	J:93333
Cellular Component	GO:0005634	nucleus	IDA	J:93333
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IGI	J:98103
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:98103
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:97306
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0097190	apoptotic signaling pathway	IEA	J:72247
Biological Process	GO:0007420	brain development	IMP	J:49841
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0030900	forebrain development	IMP	J:41353
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	NAS	J:320091
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:219625
Biological Process	GO:0007275	multicellular organism development	IMP	J:49840
Biological Process	GO:0001843	neural tube closure	IMP	J:41353
Biological Process	GO:0001843	neural tube closure	IMP	J:71086
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:98103
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:101402
Biological Process	GO:1902510	regulation of apoptotic DNA fragmentation	IGI	J:98103
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247