Lrp6 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034185	apolipoprotein binding	IPI	J:155275
Molecular Function	GO:0071936	coreceptor activity involved in Wnt signaling pathway	ISO	J:164563
Molecular Function	GO:0005109	frizzled binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019210	kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	ISO	J:103781
Molecular Function	GO:0005515	protein binding	IPI	J:274568
Molecular Function	GO:0005515	protein binding	IPI	J:273584
Molecular Function	GO:0005515	protein binding	IPI	J:154861
Molecular Function	GO:0005515	protein binding	IPI	J:273507
Molecular Function	GO:0005515	protein binding	IPI	J:163129
Molecular Function	GO:0005515	protein binding	IPI	J:155275
Molecular Function	GO:0005515	protein binding	IPI	J:153413
Molecular Function	GO:0005515	protein binding	IPI	J:163977
Molecular Function	GO:0005515	protein binding	IPI	J:110693
Molecular Function	GO:0005515	protein binding	IPI	J:101423
Molecular Function	GO:0005515	protein binding	IPI	J:145745
Molecular Function	GO:0005515	protein binding	IPI	J:101423
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0019534	toxin transmembrane transporter activity	IMP	J:166019
Molecular Function	GO:0042813	Wnt receptor activity	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	ISO	J:164563
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:140886
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:155275
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:101423
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:103781
Cellular Component	GO:0005886	plasma membrane	IDA	J:153413
Cellular Component	GO:0005886	plasma membrane	IDA	J:155275
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:1990909	Wnt signalosome	ISO	J:164563
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	ISO	J:164563
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:155226
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:101423
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:91055
Biological Process	GO:0003401	axis elongation	IMP	J:155226
Biological Process	GO:0090245	axis elongation involved in somitogenesis	IGI	J:64989
Biological Process	GO:0060349	bone morphogenesis	IMP	MGI:MGI:61254
Biological Process	GO:0046849	bone remodeling	IGI	J:111359
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:150203
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:155226
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:101423
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:90938
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:93008
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:153413
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:103781
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:91019
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:64989
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:131960
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:156508
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:152320
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:73065
Biological Process	GO:0061310	canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development	IMP	J:155248
Biological Process	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	IMP	J:155248
Biological Process	GO:0042074	cell migration involved in gastrulation	IGI	J:91055
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:155856
Biological Process	GO:0071397	cellular response to cholesterol	ISO	J:164563
Biological Process	GO:0021587	cerebellum morphogenesis	IMP	J:64989
Biological Process	GO:0021795	cerebral cortex cell migration	IMP	J:114451
Biological Process	GO:0021987	cerebral cortex development	IMP	J:114451
Biological Process	GO:0007268	chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0060026	convergent extension	IGI	J:155226
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:155225
Biological Process	GO:0009950	dorsal/ventral axis specification	IMP	J:143210
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:155250
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:143210
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:155226
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:91055
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:98369
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IMP	J:155250
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:131960
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IMP	J:64989
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IGI	J:98369
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:98369
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:155250
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:98369
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:131960
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:161416
Biological Process	GO:0009880	embryonic pattern specification	IMP	J:155250
Biological Process	GO:0009880	embryonic pattern specification	IMP	J:155250
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	IMP	J:155250
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0060856	establishment of blood-brain barrier	IMP	J:215763
Biological Process	GO:1990963	establishment of blood-retinal barrier	IMP	J:215763
Biological Process	GO:0035261	external genitalia morphogenesis	IMP	J:155250
Biological Process	GO:0035261	external genitalia morphogenesis	IMP	J:155250
Biological Process	GO:0060325	face morphogenesis	IMP	J:152320
Biological Process	GO:0060325	face morphogenesis	IMP	J:155250
Biological Process	GO:0045444	fat cell differentiation	IMP	J:127355
Biological Process	GO:0030900	forebrain development	IMP	J:93195
Biological Process	GO:0021872	forebrain generation of neurons	IMP	J:87386
Biological Process	GO:0021861	forebrain radial glial cell differentiation	IGI	J:87386
Biological Process	GO:0021943	formation of radial glial scaffolds	IGI	J:87386
Biological Process	GO:0001702	gastrulation with mouth forming second	IGI	J:91055
Biological Process	GO:0048699	generation of neurons	IMP	J:109778
Biological Process	GO:0001947	heart looping	IGI	J:155226
Biological Process	GO:0035108	limb morphogenesis	IGI	J:111359
Biological Process	GO:0035108	limb morphogenesis	IMP	J:93008
Biological Process	GO:0060603	mammary gland duct morphogenesis	IGI	J:150203
Biological Process	GO:0060596	mammary placode formation	IMP	J:150203
Biological Process	GO:0010463	mesenchymal cell proliferation	IMP	J:152320
Biological Process	GO:0008078	mesodermal cell migration	IGI	J:91055
Biological Process	GO:0030901	midbrain development	IMP	J:64989
Biological Process	GO:0030917	midbrain-hindbrain boundary development	IMP	J:64989
Biological Process	GO:0030917	midbrain-hindbrain boundary development	IMP	J:155226
Biological Process	GO:0002009	morphogenesis of an epithelium	IMP	MGI:MGI:61211
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:152320
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:152320
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:152320
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:127355
Biological Process	GO:2000051	negative regulation of non-canonical Wnt signaling pathway	IGI	J:163977
Biological Process	GO:2000151	negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IGI	J:163977
Biological Process	GO:2000162	negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis	IGI	J:163977
Biological Process	GO:2000168	negative regulation of planar cell polarity pathway involved in neural tube closure	IGI	J:163977
Biological Process	GO:2000164	negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis	IGI	J:163977
Biological Process	GO:2000166	negative regulation of planar cell polarity pathway involved in pericardium morphogenesis	IGI	J:163977
Biological Process	GO:2000149	negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis	IGI	J:163977
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:0014033	neural crest cell differentiation	ISO	J:164563
Biological Process	GO:0014029	neural crest formation	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:155250
Biological Process	GO:0001843	neural tube closure	IMP	J:93008
Biological Process	GO:0001843	neural tube closure	IMP	J:58433
Biological Process	GO:0001843	neural tube closure	IGI	J:155226
Biological Process	GO:0001843	neural tube closure	IMP	MGI:MGI:61254
Biological Process	GO:0021915	neural tube development	IGI	J:155226
Biological Process	GO:0110135	Norrin signaling pathway	IDA	J:107732
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	MGI:MGI:61254
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	MGI:MGI:61211
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:12999
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:5905
Biological Process	GO:0003344	pericardium morphogenesis	IGI	J:155226
Biological Process	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IGI	J:163977
Biological Process	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IGI	J:163977
Biological Process	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IGI	J:163977
Biological Process	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IGI	J:163977
Biological Process	GO:0061350	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IGI	J:163977
Biological Process	GO:0061349	planar cell polarity pathway involved in cardiac right atrium morphogenesis	IGI	J:163977
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:163977
Biological Process	GO:0061347	planar cell polarity pathway involved in outflow tract morphogenesis	IGI	J:163977
Biological Process	GO:0061354	planar cell polarity pathway involved in pericardium morphogenesis	IGI	J:163977
Biological Process	GO:0061348	planar cell polarity pathway involved in ventricular septum morphogenesis	IGI	J:163977
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:152320
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:152320
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:152320
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:153413
Biological Process	GO:0045787	positive regulation of cell cycle	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:107732
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:107732
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:152320
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:152320
Biological Process	GO:0010976	positive regulation of neuron projection development	IGI	J:239196
Biological Process	GO:0045778	positive regulation of ossification	IMP	J:93008
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:152320
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:152320
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	J:155226
Biological Process	GO:0036342	post-anal tail morphogenesis	IGI	J:155226
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	J:155250
Biological Process	GO:0090009	primitive streak formation	IGI	J:155226
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	IBA	J:265628
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	IMP	J:155275
Biological Process	GO:0060284	regulation of cell development	IMP	J:155225
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:5905
Biological Process	GO:0051593	response to folic acid	IMP	J:117752
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:143210
Biological Process	GO:0060021	roof of mouth development	IMP	J:155250
Biological Process	GO:0060021	roof of mouth development	IMP	J:152320
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:93008
Biological Process	GO:0001756	somitogenesis	IGI	J:155226
Biological Process	GO:0072089	stem cell proliferation	IMP	J:152320
Biological Process	GO:0021794	thalamus development	IMP	J:109778
Biological Process	GO:0060535	trachea cartilage morphogenesis	IGI	J:131960
Biological Process	GO:0016055	Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	IGI	J:87386
Biological Process	GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	IMP	J:114451
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IBA	J:265628
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IMP	J:93008

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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