GO Annotations Graph

• Symbol: Npc1
• Name: NPC intracellular cholesterol transporter 1
• ID: MGI:1097712

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0015485	cholesterol binding	IBA	J:265628
Molecular Function	GO:0005319	lipid transporter activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:314093
Molecular Function	GO:0005515	protein binding	IPI	J:180176
Molecular Function	GO:0005515	protein binding	IPI	J:110348
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005768	endosome	IDA	J:120537
Cellular Component	GO:0005768	endosome	IDA	J:110348
Cellular Component	GO:0005768	endosome	IDA	J:120537
Cellular Component	GO:0005576	extracellular region	IDA	J:180176
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:120537
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:180176
Cellular Component	GO:0005764	lysosome	IDA	J:176587
Cellular Component	GO:0005764	lysosome	IDA	J:170933
Cellular Component	GO:0005764	lysosome	IDA	J:120537
Cellular Component	GO:0005764	lysosome	IDA	J:120537
Cellular Component	GO:0016020	membrane	IDA	J:120537
Cellular Component	GO:0045121	membrane raft	IDA	J:120537
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	IDA	J:160544
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:120537
Cellular Component	GO:0031982	vesicle	IDA	J:120537
Biological Process	GO:0007628	adult walking behavior	IGI	J:145003
Biological Process	GO:0006914	autophagy	ISO	J:145003
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	IDA	J:120537
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	IDA	J:120537
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0033344	cholesterol efflux	IMP	J:120283
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:176587
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0010878	cholesterol storage	IMP	J:173597
Biological Process	GO:0030301	cholesterol transport	ISO	J:164563
Biological Process	GO:0030301	cholesterol transport	IMP	J:173597
Biological Process	GO:2000900	cyclodextrin metabolic process	IMP	J:173597
Biological Process	GO:0006897	endocytosis	IMP	J:91039
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:120283
Biological Process	GO:0090150	establishment of protein localization to membrane	ISO	J:164563
Biological Process	GO:0010467	gene expression	IMP	J:263829
Biological Process	GO:0010467	gene expression	IMP	J:170933
Biological Process	GO:0030299	intestinal cholesterol absorption	IBA	J:265628
Biological Process	GO:0032367	intracellular cholesterol transport	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0001889	liver development	IMP	J:170933
Biological Process	GO:0016236	macroautophagy	IMP	J:125097
Biological Process	GO:0016236	macroautophagy	IGI	J:125097
Biological Process	GO:0016236	macroautophagy	IMP	J:125097
Biological Process	GO:0016236	macroautophagy	IMP	J:125097
Biological Process	GO:0031579	membrane raft organization	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0016242	negative regulation of macroautophagy	IGI	J:125097
Biological Process	GO:0016242	negative regulation of macroautophagy	IMP	J:125097
Biological Process	GO:1904262	negative regulation of TORC1 signaling	ISO	J:164563
Biological Process	GO:0022008	neurogenesis	IMP	J:173597
Biological Process	GO:0012501	programmed cell death	IMP	J:173597
Biological Process	GO:0006486	protein glycosylation	ISO	J:164563
Biological Process	GO:0006486	protein glycosylation	IDA	J:180176
Biological Process	GO:0046686	response to cadmium ion	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:120537
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0016125	sterol metabolic process	IMP	J:170933
Biological Process	GO:0016125	sterol metabolic process	IMP	J:173597
Biological Process	GO:0015918	sterol transport	IMP	J:170933
Biological Process	GO:0046718	viral entry into host cell	IMP	J:219073
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563
Biological Process	GO:0046718	viral entry into host cell	IMP	J:176235