GO Annotations Graph

• Symbol: Aqp2
• Name: aquaporin 2
• ID: MGI:1096865

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0015267	channel activity	IEA	J:72247
Molecular Function	GO:0015168	glycerol transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0015250	water channel activity	ISO	J:164563
Molecular Function	GO:0015250	water channel activity	IBA	J:265628
Molecular Function	GO:0015250	water channel activity	IDA	J:47478
Molecular Function	GO:0005372	water transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005372	water transmembrane transporter activity	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:234905
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:54490
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:186879
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:103213
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:95502
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:234905
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:139769
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0010008	endosome membrane	IC	J:47478
Cellular Component	GO:0010008	endosome membrane	IC	J:47478
Cellular Component	GO:0070382	exocytic vesicle	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0098576	lumenal side of membrane	IDA	J:148154
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:104785
Cellular Component	GO:0016020	membrane	ISM	J:47478
Cellular Component	GO:0016020	membrane	ISO	J:197701
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:234905
Cellular Component	GO:0005886	plasma membrane	IDA	J:110350
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IC	J:47478
Cellular Component	GO:0005886	plasma membrane	IC	J:47478
Cellular Component	GO:0005886	plasma membrane	IDA	J:47478
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0055037	recycling endosome	IDA	J:47478
Cellular Component	GO:0055038	recycling endosome membrane	IC	J:47478
Cellular Component	GO:0055038	recycling endosome membrane	IC	J:47478
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Cellular Component	GO:0030133	transport vesicle	ISO	J:155856
Biological Process	GO:0030042	actin filament depolymerization	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0006884	cell volume homeostasis	ISO	J:155856
Biological Process	GO:0071280	cellular response to copper ion	ISO	J:164563
Biological Process	GO:0071288	cellular response to mercury ion	ISO	J:164563
Biological Process	GO:0042631	cellular response to water deprivation	ISO	J:155856
Biological Process	GO:0042631	cellular response to water deprivation	IDA	J:47478
Biological Process	GO:0015793	glycerol transmembrane transport	ISO	J:164563
Biological Process	GO:0072205	metanephric collecting duct development	IEP	J:138858
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0003091	renal water homeostasis	ISO	J:164563
Biological Process	GO:0003091	renal water homeostasis	IDA	J:234905
Biological Process	GO:0003097	renal water transport	IMP	J:9451
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0006833	water transport	ISO	J:155856
Biological Process	GO:0006833	water transport	ISO	J:164563
Biological Process	GO:0006833	water transport	IBA	J:265628
Biological Process	GO:0006833	water transport	IDA	J:47478