GO Annotations Graph

• Symbol: Irs2
• Name: insulin receptor substrate 2
• ID: MGI:109334

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	ISO	J:155856
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0005158	insulin receptor binding	IBA	J:265628
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:110842
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:23766
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IBA	J:265628
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IDA	J:107119
Molecular Function	GO:0005515	protein binding	IPI	J:247388
Molecular Function	GO:0005515	protein binding	IPI	J:128457
Molecular Function	GO:0005515	protein binding	IPI	J:230033
Molecular Function	GO:0005515	protein binding	IPI	J:230404
Molecular Function	GO:0005515	protein binding	IPI	J:230404
Molecular Function	GO:0005515	protein binding	IPI	J:230404
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IDA	J:87936
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:110842
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:23766
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-198263
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-198275
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671830
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671841
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006326
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006327
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006329
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012652
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012653
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012656
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027266
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027429
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027436
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029147
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029162
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9030346
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9030353
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9032476
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:125126
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:107119
Cellular Component	GO:0032991	protein-containing complex	IDA	J:230033
Biological Process	GO:0007420	brain development	IMP	J:84857
Biological Process	GO:0016477	cell migration	IGI	J:124667
Biological Process	GO:0008283	cell population proliferation	IGI	J:125126
Biological Process	GO:0008283	cell population proliferation	IMP	J:84857
Biological Process	GO:0008283	cell population proliferation	IGI	J:125126
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:107119
Biological Process	GO:0010631	epithelial cell migration	IGI	J:124667
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:110842
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:23766
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:23766
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:230404
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:80826
Biological Process	GO:0030879	mammary gland development	IGI	J:124667
Biological Process	GO:0030879	mammary gland development	IGI	J:124667
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	IMP	J:161023
Biological Process	GO:0033673	negative regulation of kinase activity	IMP	J:150650
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	ISO	J:164563
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:161023
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:84857
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IGI	J:124667
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	ISO	J:164563
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0010907	positive regulation of glucose metabolic process	ISO	J:164563
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:161023
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IGI	J:124667
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:0009749	response to glucose	IDA	J:161023
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:125126
Biological Process	GO:0044342	type B pancreatic cell proliferation	IGI	J:125126