Smo GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smo
smoothened, frizzled class receptor
MGI:108075

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0005113	patched binding	ISO	J:164563
Molecular Function	GO:0005113	patched binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:218232
Molecular Function	GO:0005515	protein binding	IPI	J:259132
Molecular Function	GO:0005515	protein binding	IPI	J:323230
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0097731	9+0 non-motile cilium	IDA	J:236749
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005814	centriole	IDA	J:255486
Cellular Component	GO:0060170	ciliary membrane	TAS	Reactome:R-MMU-5632658
Cellular Component	GO:0060170	ciliary membrane	TAS	Reactome:R-MMU-5632661
Cellular Component	GO:0060170	ciliary membrane	TAS	Reactome:R-MMU-5632663
Cellular Component	GO:0060170	ciliary membrane	TAS	Reactome:R-MMU-5632665
Cellular Component	GO:0060170	ciliary membrane	TAS	Reactome:R-MMU-5633169
Cellular Component	GO:0060170	ciliary membrane	IDA	J:178978
Cellular Component	GO:0005929	cilium	IDA	J:168317
Cellular Component	GO:0005929	cilium	IDA	J:259132
Cellular Component	GO:0005929	cilium	IDA	J:218232
Cellular Component	GO:0005929	cilium	IDA	J:168317
Cellular Component	GO:0005929	cilium	ISO	J:164563
Cellular Component	GO:0005929	cilium	IBA	J:265628
Cellular Component	GO:0005929	cilium	IMP	J:240898
Cellular Component	GO:0005929	cilium	IDA	J:151923
Cellular Component	GO:0005929	cilium	IDA	J:103514
Cellular Component	GO:0005929	cilium	IDA	J:138139
Cellular Component	GO:0005929	cilium	IDA	J:153142
Cellular Component	GO:0005929	cilium	IDA	J:102118
Cellular Component	GO:0005929	cilium	IDA	J:323230
Cellular Component	GO:0005929	cilium	ISO	J:236236
Cellular Component	GO:0005929	cilium	IDA	J:246963
Cellular Component	GO:0005929	cilium	IDA	J:260445
Cellular Component	GO:0005929	cilium	IDA	J:185270
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:138139
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0044294	dendritic growth cone	ISO	J:155856
Cellular Component	GO:0030666	endocytic vesicle membrane	TAS	Reactome:R-MMU-5632657
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:323230
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IDA	J:323230
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:323230
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:323230
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005770	late endosome	IDA	J:323230
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:180534
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:323230
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0071929	alpha-tubulin acetylation	IMP	J:240898
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:187741
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:187741
Biological Process	GO:0006915	apoptotic process	IMP	J:108509
Biological Process	GO:0006915	apoptotic process	IMP	J:323230
Biological Process	GO:0006915	apoptotic process	IMP	J:108509
Biological Process	GO:0006915	apoptotic process	IMP	J:108509
Biological Process	GO:0048143	astrocyte activation	IMP	J:201110
Biological Process	GO:0060413	atrial septum morphogenesis	IGI	J:187715
Biological Process	GO:0048846	axon extension involved in axon guidance	ISO	J:155856
Biological Process	GO:0048468	cell development	IMP	J:80081
Biological Process	GO:0048468	cell development	IMP	J:80081
Biological Process	GO:0001708	cell fate specification	IMP	J:138713
Biological Process	GO:0008283	cell population proliferation	IMP	J:146198
Biological Process	GO:0008283	cell population proliferation	IMP	J:80081
Biological Process	GO:0008283	cell population proliferation	IMP	J:80081
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0071397	cellular response to cholesterol	IEP	J:180534
Biological Process	GO:0007417	central nervous system development	IBA	J:265628
Biological Process	GO:0007417	central nervous system development	IGI	J:80206
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:108509
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:108509
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:108509
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:108509
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:108509
Biological Process	GO:0021953	central nervous system neuron differentiation	IMP	J:108509
Biological Process	GO:0021696	cerebellar cortex morphogenesis	IMP	J:108507
Biological Process	GO:0021987	cerebral cortex development	IMP	J:201110
Biological Process	GO:0071679	commissural neuron axon guidance	ISO	J:155856
Biological Process	GO:0071679	commissural neuron axon guidance	IBA	J:265628
Biological Process	GO:0060242	contact inhibition	ISO	J:164563
Biological Process	GO:0021542	dentate gyrus development	IMP	J:135664
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	IMP	J:175111
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:98216
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:79831
Biological Process	GO:0048589	developmental growth	IMP	J:108509
Biological Process	GO:0048589	developmental growth	IMP	J:108509
Biological Process	GO:0048589	developmental growth	IMP	J:108509
Biological Process	GO:0048565	digestive tract development	IMP	J:151981
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:108509
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:108509
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:138713
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:108509
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:108509
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:108509
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:98216
Biological Process	GO:0048568	embryonic organ development	IGI	J:205269
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:117334
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:80081
Biological Process	GO:0060684	epithelial-mesenchymal cell signaling	IMP	J:147277
Biological Process	GO:0048853	forebrain morphogenesis	IMP	J:175111
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0010467	gene expression	IDA	J:192563
Biological Process	GO:0001942	hair follicle development	IMP	J:117334
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:117334
Biological Process	GO:0001947	heart looping	IMP	J:175111
Biological Process	GO:0003007	heart morphogenesis	IGI	J:110602
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IDA	J:201110
Biological Process	GO:0001701	in utero embryonic development	IMP	J:128367
Biological Process	GO:0070986	left/right axis specification	IMP	J:48268
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IMP	J:117334
Biological Process	GO:0060231	mesenchymal to epithelial transition	ISO	J:155856
Biological Process	GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation	IMP	J:104380
Biological Process	GO:0007494	midgut development	IMP	J:175111
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IGI	J:138713
Biological Process	GO:0035264	multicellular organism growth	IMP	J:138713
Biological Process	GO:0051451	myoblast migration	IGI	J:187741
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:108509
Biological Process	GO:0043392	negative regulation of DNA binding	IMP	J:104380
Biological Process	GO:0043392	negative regulation of DNA binding	IGI	J:104380
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:219044
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	IMP	J:117334
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:104380
Biological Process	GO:0051799	negative regulation of hair follicle development	IMP	J:117334
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0001755	neural crest cell migration	IGI	J:110602
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:106707
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:106707
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:80081
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:117334
Biological Process	GO:0001503	ossification	IMP	J:73071
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:88635
Biological Process	GO:0061113	pancreas morphogenesis	IMP	J:164411
Biological Process	GO:0007389	pattern specification process	IBA	J:265628
Biological Process	GO:0007389	pattern specification process	IMP	J:89445
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:155856
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:104380
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:146198
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:219044
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:80081
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:147277
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:104380
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:201110
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:0007228	positive regulation of hh target transcription factor activity	IMP	J:175111
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IMP	J:147277
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:219044
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IGI	J:106707
Biological Process	GO:0046622	positive regulation of organ growth	IMP	J:219044
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IGI	J:113403
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IGI	J:113403
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	IMP	J:105834
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:98927
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:147277
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0006606	protein import into nucleus	IGI	J:113403
Biological Process	GO:0006606	protein import into nucleus	IGI	J:113403
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:154728
Biological Process	GO:0050821	protein stabilization	IDA	J:146198
Biological Process	GO:0010468	regulation of gene expression	IGI	J:138713
Biological Process	GO:2000826	regulation of heart morphogenesis	IMP	J:175111
Biological Process	GO:1904672	regulation of somatic stem cell population maintenance	IMP	J:117334
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:187741
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:175111
Biological Process	GO:0007224	smoothened signaling pathway	ISO	J:164563
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:175319
Biological Process	GO:0007224	smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:240898
Biological Process	GO:0007224	smoothened signaling pathway	IGI	J:113403
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:164411
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:117334
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:102118
Biological Process	GO:0007224	smoothened signaling pathway	IGI	J:113403
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:117334
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:89445
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:323230
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:260445
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	IMP	J:108507
Biological Process	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	IMP	J:168317
Biological Process	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	IMP	J:147574
Biological Process	GO:0061053	somite development	IMP	J:175111
Biological Process	GO:0021794	thalamus development	IMP	J:147427
Biological Process	GO:0003323	type B pancreatic cell development	IMP	J:164411
Biological Process	GO:0001570	vasculogenesis	IMP	J:92048
Biological Process	GO:0001570	vasculogenesis	IMP	J:128367
Biological Process	GO:0007371	ventral midline determination	IMP	J:175111

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