GO Annotations Graph

• Symbol: Traf6
• Name: TNF receptor-associated factor 6
• ID: MGI:108072

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:131466
Molecular Function	GO:0005515	protein binding	IPI	J:201886
Molecular Function	GO:0005515	protein binding	IPI	J:118130
Molecular Function	GO:0005515	protein binding	IPI	J:174433
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:186456
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:113963
Molecular Function	GO:0005515	protein binding	IPI	J:113967
Molecular Function	GO:0005515	protein binding	IPI	J:172275
Molecular Function	GO:0005515	protein binding	IPI	J:206904
Molecular Function	GO:0005515	protein binding	IPI	J:304571
Molecular Function	GO:0005515	protein binding	IPI	J:169840
Molecular Function	GO:0005515	protein binding	IPI	J:54076
Molecular Function	GO:0005515	protein binding	IPI	J:36721
Molecular Function	GO:0005515	protein binding	IPI	J:176466
Molecular Function	GO:0005515	protein binding	IPI	J:180054
Molecular Function	GO:0005515	protein binding	IPI	J:87840
Molecular Function	GO:0005515	protein binding	IPI	J:131849
Molecular Function	GO:0005515	protein binding	IPI	J:57233
Molecular Function	GO:0005515	protein binding	IPI	J:109625
Molecular Function	GO:0005515	protein binding	IPI	J:144594
Molecular Function	GO:0005515	protein binding	IPI	J:200301
Molecular Function	GO:0005515	protein binding	IPI	J:260559
Molecular Function	GO:0005515	protein binding	IPI	J:187586
Molecular Function	GO:0005515	protein binding	IPI	J:188556
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	IEA	J:72247
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	IBA	J:265628
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	ISO	J:205449
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:103614
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IMP	J:188556
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IDA	J:103614
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0035631	CD40 receptor complex	IDA	J:161997
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:161997
Cellular Component	GO:0005829	cytosol	IDA	J:116495
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-205060
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-933534
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	IDA	J:169840
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098802	plasma membrane signaling receptor complex	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:205449
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	ISO	J:164563
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:97344
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP	J:85808
Biological Process	GO:0046849	bone remodeling	IMP	J:77453
Biological Process	GO:0045453	bone resorption	IMP	J:54467
Biological Process	GO:0048468	cell development	IMP	J:97344
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:205449
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:159274
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:187586
Biological Process	GO:0006955	immune response	IMP	J:97344
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0001701	in utero embryonic development	IMP	J:240631
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IMP	J:77453
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IMP	J:260559
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IDA	J:260559
Biological Process	GO:0038173	interleukin-17A-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IGI	J:229024
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:229024
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IMP	J:85808
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:77302
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:87318
Biological Process	GO:0001503	ossification	IMP	J:54467
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:77453
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:198907
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:92728
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:187586
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:85808
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:85808
Biological Process	GO:0046330	positive regulation of JNK cascade	IBA	J:265628
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	ISO	J:164563
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IMP	J:54467
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:198907
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0002726	positive regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:77453
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	TAS	J:112607
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:205449
Biological Process	GO:0070534	protein K63-linked ubiquitination	IDA	J:103614
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IMP	J:260559
Biological Process	GO:0016567	protein ubiquitination	IGI	J:180378
Biological Process	GO:0016567	protein ubiquitination	IDA	J:188556
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0002637	regulation of immunoglobulin production	IDA	J:86592
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IDA	J:86592
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042088	T-helper 1 type immune response	IMP	J:85808
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IBA	J:265628