GO Annotations Graph

• Symbol: Bcl2l2
• Name: BCL2-like 2
• ID: MGI:108052

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051400	BH domain binding	ISO	J:155856
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:203396
Molecular Function	GO:0005515	protein binding	IPI	J:78230
Molecular Function	GO:0005515	protein binding	IPI	J:74519
Molecular Function	GO:0005515	protein binding	IPI	J:78230
Molecular Function	GO:0005515	protein binding	IPI	J:132234
Molecular Function	GO:0046982	protein heterodimerization activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0097136	Bcl-2 family protein complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:76215
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:76215
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:78230
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0035795	negative regulation of mitochondrial membrane permeability	ISO	J:155856
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0060011	Sertoli cell proliferation	IGI	J:72582