GO Annotations Graph

• Symbol: Prkar2a
• Name: protein kinase, cAMP dependent regulatory, type II alpha
• ID: MGI:108025

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0030552	cAMP binding	ISO	J:155856
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	ISO	J:155856
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:126951
Molecular Function	GO:0005515	protein binding	IPI	J:126951
Molecular Function	GO:0005515	protein binding	IPI	J:52123
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:190017
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0036094	small molecule binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005930	axoneme	ISO	J:164563
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	ISO	J:155856
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	ISO	J:164563
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	IDA	J:177007
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:177007
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9010662
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:100342
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:100342
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:206458
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:206458
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:206458
Cellular Component	GO:0045202	synapse	EXP	J:206458
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:100342
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:100342
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:0045859	regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0001932	regulation of protein phosphorylation	IEA	J:72247