GO Annotations Graph

• Symbol: Casp4
• Name: caspase 4, apoptosis-related cysteine peptidase
• ID: MGI:107700

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050700	CARD domain binding	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:319864
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IMP	J:267416
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:296118
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:265832
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:265832
Molecular Function	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0001530	lipopolysaccharide binding	ISO	J:164563
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:332656
Molecular Function	GO:0001530	lipopolysaccharide binding	IDA	J:332656
Molecular Function	GO:0008233	peptidase activity	RCA	J:84168
Molecular Function	GO:0005515	protein binding	IPI	J:273511
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Cellular Component	GO:0061702	canonical inflammasome complex	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:131780
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:131780
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0072558	NLRP1 inflammasome complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	TAS	J:180458
Biological Process	GO:0140632	canonical inflammasome complex assembly	IMP	J:332990
Biological Process	GO:0140632	canonical inflammasome complex assembly	IDA	J:201144
Biological Process	GO:0140632	canonical inflammasome complex assembly	IDA	J:201075
Biological Process	GO:0140632	canonical inflammasome complex assembly	IDA	J:333171
Biological Process	GO:0042742	defense response to bacterium	IMP	J:193387
Biological Process	GO:0042742	defense response to bacterium	IDA	J:332656
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:267416
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:333171
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:201144
Biological Process	GO:0032497	detection of lipopolysaccharide	IDA	J:201075
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:115619
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:115619
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032611	interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:193522
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:193522
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:265832
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:332656
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:265832
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	IDA	J:332656
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:193387
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:319864
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:267416
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IGI	J:193522
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IDA	J:267416
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:193522
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:193522
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:233045
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0016540	protein autoprocessing	IDA	J:296118
Biological Process	GO:0016540	protein autoprocessing	IMP	J:267416
Biological Process	GO:0051604	protein maturation	IDA	J:265832
Biological Process	GO:0051604	protein maturation	IDA	J:265832
Biological Process	GO:0006508	proteolysis	RCA	J:84168
Biological Process	GO:0070269	pyroptosis	IDA	J:296118
Biological Process	GO:0070269	pyroptosis	IDA	J:333171
Biological Process	GO:0070269	pyroptosis	IDA	J:265832
Biological Process	GO:0070269	pyroptosis	IMP	J:193387
Biological Process	GO:0070269	pyroptosis	IDA	J:319864
Biological Process	GO:0070269	pyroptosis	IMP	J:193522
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0050727	regulation of inflammatory response	IDA	J:296118