GO Annotations Graph

• Symbol: Aqp4
• Name: aquaporin 4
• ID: MGI:107387

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015267	channel activity	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:169095
Molecular Function	GO:0015250	water channel activity	IDA	J:32891
Molecular Function	GO:0015250	water channel activity	ISO	J:155856
Molecular Function	GO:0015250	water channel activity	IDA	J:273546
Molecular Function	GO:0015250	water channel activity	ISO	J:164563
Molecular Function	GO:0015250	water channel activity	IBA	J:265628
Cellular Component	GO:0097450	astrocyte end-foot	IDA	J:187150
Cellular Component	GO:0097450	astrocyte end-foot	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:260928
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:176751
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:186879
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:53078
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:60362
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:60362
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0031253	cell projection membrane	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:173745
Cellular Component	GO:0005911	cell-cell junction	IDA	J:104866
Cellular Component	GO:0005737	cytoplasm	IDA	J:173745
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	NAS	J:32891
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:173745
Cellular Component	GO:0005886	plasma membrane	IDA	J:273546
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:116293
Cellular Component	GO:0005886	plasma membrane	TAS	J:65472
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:273559
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Biological Process	GO:0015670	carbon dioxide transport	ISO	J:155856
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:155856
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0090660	cerebrospinal fluid circulation	IMP	J:187150
Biological Process	GO:0033326	cerebrospinal fluid secretion	IMP	J:270455
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:106259
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:106259
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:106259
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:106259
Biological Process	GO:0009992	intracellular water homeostasis	ISO	J:155856
Biological Process	GO:0009992	intracellular water homeostasis	IDA	J:273546
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	IDA	J:260928
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	IMP	J:105929
Biological Process	GO:0060354	negative regulation of cell adhesion molecule production	ISO	J:155856
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	ISO	J:155856
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	ISO	J:155856
Biological Process	GO:0070295	renal water absorption	IMP	J:62449
Biological Process	GO:0070295	renal water absorption	IMP	J:60362
Biological Process	GO:0070295	renal water absorption	IGI	J:60362
Biological Process	GO:0007605	sensory perception of sound	IMP	J:71154
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0006833	water transport	IDA	J:273546
Biological Process	GO:0006833	water transport	ISO	J:155856
Biological Process	GO:0006833	water transport	ISO	J:164563
Biological Process	GO:0006833	water transport	IBA	J:265628
Biological Process	GO:0006833	water transport	IMP	J:106259
Biological Process	GO:0006833	water transport	IMP	J:106259
Biological Process	GO:0006833	water transport	IMP	J:106259
Biological Process	GO:0006833	water transport	IMP	J:106259
Biological Process	GO:0006833	water transport	TAS	J:65472