GO Annotations Graph

• Symbol: Ctsh
• Name: cathepsin H
• ID: MGI:107285

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004177	aminopeptidase activity	ISO	J:155856
Molecular Function	GO:0004177	aminopeptidase activity	ISO	J:164563
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IGI	J:165930
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IBA	J:265628
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IDA	J:124592
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:180481
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0030108	HLA-A specific activating MHC class I receptor activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0030984	kininogen binding	ISO	J:155856
Molecular Function	GO:0016505	peptidase activator activity involved in apoptotic process	IGI	J:165930
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0043621	protein self-association	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0004252	serine-type endopeptidase activity	IMP	J:165930
Molecular Function	GO:0070324	thyroid hormone binding	ISO	J:164563
Cellular Component	GO:0001669	acrosomal vesicle	ISO	J:155856
Cellular Component	GO:0097208	alveolar lamellar body	ISO	J:155856
Cellular Component	GO:0097208	alveolar lamellar body	ISO	J:164563
Cellular Component	GO:0005930	axoneme	ISO	J:155856
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IBA	J:265628
Cellular Component	GO:0001520	outer dense fiber	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IGI	J:165930
Biological Process	GO:0010815	bradykinin catabolic process	ISO	J:164563
Biological Process	GO:0060448	dichotomous subdivision of terminal units involved in lung branching	IMP	J:124592
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0002764	immune response-regulating signaling pathway	ISO	J:164563
Biological Process	GO:0033619	membrane protein proteolysis	IMP	J:180481
Biological Process	GO:0033619	membrane protein proteolysis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:180547
Biological Process	GO:0010813	neuropeptide catabolic process	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:180547
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:165930
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:180547
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IMP	J:124592
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010952	positive regulation of peptidase activity	ISO	J:164563
Biological Process	GO:0010952	positive regulation of peptidase activity	IGI	J:165930
Biological Process	GO:0010952	positive regulation of peptidase activity	IBA	J:265628
Biological Process	GO:0031648	protein destabilization	IMP	J:124592
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IMP	J:165930
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	IBA	J:265628
Biological Process	GO:0032526	response to retinoic acid	IDA	J:124592
Biological Process	GO:0043129	surfactant homeostasis	ISO	J:164563
Biological Process	GO:0001913	T cell mediated cytotoxicity	IGI	J:165930
Biological Process	GO:0031638	zymogen activation	ISO	J:164563
Biological Process	GO:0031638	zymogen activation	IMP	J:165930