GO Annotations Graph

• Symbol: Was
• Name: Wiskott-Aldrich syndrome
• ID: MGI:105059

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IDA	J:79320
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:65771
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:283192
Molecular Function	GO:0005515	protein binding	IPI	J:164711
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-442572
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:143718
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0012506	vesicle membrane	IDA	J:79320
Biological Process	GO:0007015	actin filament organization	IEA	J:72247
Biological Process	GO:0030041	actin filament polymerization	ISO	J:164563
Biological Process	GO:0030041	actin filament polymerization	IDA	J:79320
Biological Process	GO:0030048	actin filament-based movement	IDA	J:79320
Biological Process	GO:0008154	actin polymerization or depolymerization	IDA	J:79320
Biological Process	GO:0032488	Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:143718
Biological Process	GO:0016197	endosomal transport	IDA	J:79320
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:2000146	negative regulation of cell motility	ISO	J:164563
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	IEA	J:72247
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0008064	regulation of actin polymerization or depolymerization	ISO	J:164563
Biological Process	GO:0010591	regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0051492	regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0002625	regulation of T cell antigen processing and presentation	ISO	J:164563
Biological Process	GO:0042110	T cell activation	IMP	J:79550