Serpine2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
MGI:101780

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005539	glycosaminoglycan binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IMP	J:155899
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:73065
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IMP	J:68075
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IGI	J:121263
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IDA	J:161338
Cellular Component	GO:0005576	extracellular region	ISO	J:73065
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:161338
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0031091	platelet alpha granule	ISO	J:73065
Biological Process	GO:0007596	blood coagulation	IMP	J:155899
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0021683	cerebellar granular layer morphogenesis	IMP	J:121263
Biological Process	GO:0061110	dense core granule biogenesis	ISO	J:155856
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	IMP	J:94811
Biological Process	GO:0060384	innervation	IMP	J:121223
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:40953
Biological Process	GO:0042628	mating plug formation	IMP	J:68075
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030195	negative regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0030195	negative regulation of blood coagulation	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	IGI	J:139818
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:139818
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IBA	J:265628
Biological Process	GO:0010466	negative regulation of peptidase activity	IMP	J:139818
Biological Process	GO:0010466	negative regulation of peptidase activity	IMP	J:94811
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IGI	J:139818
Biological Process	GO:0010757	negative regulation of plasminogen activation	ISO	J:164563
Biological Process	GO:0010757	negative regulation of plasminogen activation	IMP	J:155899
Biological Process	GO:0010757	negative regulation of plasminogen activation	IBA	J:265628
Biological Process	GO:0010544	negative regulation of platelet activation	IMP	J:155899
Biological Process	GO:0090331	negative regulation of platelet aggregation	IMP	J:155899
Biological Process	GO:0042177	negative regulation of protein catabolic process	IMP	J:111754
Biological Process	GO:0042177	negative regulation of protein catabolic process	IMP	J:94811
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:73065
Biological Process	GO:0010955	negative regulation of protein processing	IC	J:155899
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:155856
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:121263
Biological Process	GO:0010766	negative regulation of sodium ion transport	IGI	J:136460
Biological Process	GO:0010766	negative regulation of sodium ion transport	IGI	J:136460
Biological Process	GO:0010766	negative regulation of sodium ion transport	IMP	J:136460
Biological Process	GO:0010766	negative regulation of sodium ion transport	IGI	J:136460
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0030168	platelet activation	IMP	J:155899
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	IMP	J:94811
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IMP	J:94811
Biological Process	GO:0048505	regulation of timing of cell differentiation	IMP	J:121263
Biological Process	GO:0009611	response to wounding	IMP	J:121223
Biological Process	GO:0032940	secretion by cell	ISO	J:73065
Biological Process	GO:0032940	secretion by cell	IMP	J:111754
Biological Process	GO:0033363	secretory granule organization	ISO	J:155856
Biological Process	GO:0033363	secretory granule organization	IMP	J:111754
Biological Process	GO:0033363	secretory granule organization	ISO	J:73065
Biological Process	GO:0061108	seminal vesicle epithelium development	IMP	J:68075

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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