Defa12 Gene Detail

Summary

• Symbol
  Defa12
• Name
  defensin, alpha, 12
• Synonyms
  Defcr12

• Feature Type
  protein coding gene
• IDs
  MGI:99589
  NCBI Gene: 13231
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 8, Syntenic
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  DEFA1, defensin alpha 1

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DEFA1, defensin alpha 1
  
• Synonyms
  DEF1, DEFA2, HNP-1, HP-1, HP1, MRS
• Links
  HGNC:2761

  NCBI Gene ID: 1667

  UniProt: P59665

  
  
• Chr Location
  8p23.1; chr8:6977649-6980092 (-)  GRCh38

---

• Human Ortholog
  DEFA1B, defensin alpha 1B
  
• Synonyms
  HNP-1, HP-1, HP1
• Links
  HGNC:33596

  NCBI Gene ID: 728358

  UniProt: P59665

  
  
• Chr Location
  8p23.1; chr8:6996766-6999198 (-)  GRCh38

---

• Human Ortholog
  DEFA3, defensin alpha 3
  
• Synonyms
  DEF3, HNP-3, HNP3, HP-3, HP3
• Links
  HGNC:2762

  NCBI Gene ID: 1668

  UniProt: P59666

  
  
• Chr Location
  8p23.1; chr8:7015869-7018297 (-)  GRCh38

---

• Human Ortholog
  DEFA5, defensin alpha 5
  
• Synonyms
  DEF5, HD-5
• Links
  HGNC:2764

  NCBI Gene ID: 1670

  UniProt: Q01523

  
  
• Chr Location
  8p23.1; chr8:7055304-7056739 (-)  GRCh38

---

• Human Ortholog
  DEFA6, defensin alpha 6
  
• Synonyms
  DEF6, HD-6
• Links
  HGNC:2765

  NCBI Gene ID: 1671

  UniProt: Q01524

  
  
• Chr Location
  8p23.1; chr8:6924697-6926076 (-)  GRCh38

---

• MGI Vertebrate Homology
  Defa12 stringent orthology
  5 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: DEFA1, DEFA1B, DEFA3, DEFA5, DEFA6
• Protein SuperFamily
  Alpha-defensin

Expression

• cDNA Data
  1

Sequences &
Gene Models

• All Sequences
  2
• UniProt
  1

• NCBI Gene
  13231

Representative Sequences			Length	Strain/Species
transcript	U03063	GenBank | ENA | DDBJ | MGI Sequence Detail	119	C3H/HeJ
polypeptide	P50704	UniProt | EBI | MGI Sequence Detail	93	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR016327 Alpha-defensin
  IPR006081 Alpha-defensin, C-terminal
  IPR002366 Alpha-defensin, N-terminal
  IPR006080 Beta/alpha-defensin, C-terminal

Molecular
Reagents

• All nucleic 1

  cDNA 1

Other
Accession IDs

MGD-MRK-16371

References

• Summaries
  All 6
• Earliest
  J:16918 Huttner KM, et al., Structure and diversity of the murine cryptdin gene family. Genomics. 1994 Feb;19(3):448-53
• Latest
  J:156769 Amid C, et al., Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics. 2009;10:606