Si-r QTL Detail

Summary

• Symbol
  Si-r
• Name
  sucrase isomaltase, regulatory
• Synonyms
  Suc-1

• Feature Type
  QTL
• IDs
  MGI:98302
  NCBI Gene: 110158

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 3, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

This locus controls activity levels of sucrase-isomaltase in mouse intestine. The CBA/Ca strain carries a low activity determining allele; C57BL/6 and other inbred strains carry a high activity determining allele (approximately 3X higher). Heterozygotes are intermediate.

Sequences &
Gene Models

• NCBI Gene
  110158

Other
Accession IDs

MGD-MRK-14409, MGD-MRK-14641

References

• Summaries
  All 8
• Earliest
  J:8342 James PS, et al., Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine. Biochem Genet. 1986 Apr;24(3-4):169-81
• Latest
  J:151206 Babeu JP, et al., Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G124-34