Rep1 Gene Detail

Summary

• Symbol
  Rep1
• Name
  repair of chromatin damage 1
• Synonyms
  Rep-1

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:97900
  NCBI Gene: 104354
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 1, Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

Analysis of congenic strains located genes Rep1 and Rep2 controlling chromatin damage repair efficiency. NZB/NJ and BALB/cAn show inefficient repair with >100 breaks per 100 metaphase cells 2 hrs after X-irradiation of skin fibroblasts. Most strains havean efficient repair phenotype.

Sequences &
Gene Models

• NCBI Gene
  104354

Other
Accession IDs

MGD-MRK-13840, MGD-MRK-13843

References

• Summaries
  All 4
• Earliest
  J:9261 Potter M, et al., Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage. Genomics. 1988 Apr;2(3):257-62
• Latest
  J:343644 Sarkar H, et al., Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia. Biochim Biophys Acta Mol Basis Dis. 2023 Nov 20;1870(2):166963