Qdm QTL Detail

Summary

• Symbol
  Qdm
• Name
  H2-Q1 determinant modifier

• Feature Type
  QTL
• IDs
  MGI:97835
  NCBI Gene: 110042

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

This locus controls expression of certain cytotoxic T-lymphocyte defined determinants of H2-Q1. Mice carrying the H2-Dk haplotype have the recessive k allele of Qdm. Other H2-D1 haplotypes carry the dominant modifier Qdm+.

Sequences &
Gene Models

• NCBI Gene
  110042

Other
Accession IDs

MGD-MRK-13734

References

• Summaries
  All 3
• Earliest
  J:9387 Aldrich CJ, et al., Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm. Immunogenetics. 1988;28(5):334-44
• Latest
  J:184360 Renthal NE, et al., Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide. Immunogenetics. 2011 Jan;63(1):57-64