ptr Gene Detail

Summary

• Symbol
  ptr
• Name
  pulmonary tumor resistance

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:97817
  NCBI Gene: 19284
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  0 strains or lines available

This locus accounts for a major part of the difference in resistance to urethan-induced lung tumors between C57BL and A strains. C57BL carries the recessive resistance allele; A carries the dominant susceptibility allele. ptr and Pas1 may be the same.

Sequences &
Gene Models

• NCBI Gene
  19284

Other
Accession IDs

MGD-MRK-13687

References

• Summaries
  All 5

  Phenotypes 2
• Earliest
  J:232 COWEN PN, Strain differences in mice to the carcinogenic action of urethane and its non-carcinogenicity in chicks and guinea-pigs. Br J Cancer. 1950 Jun;4(2):245-53
• Latest
  J:8075 Malkinson AM, et al., Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model. J Natl Cancer Inst. 1985 Nov;75(5):971-4