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oh Gene Detail
Summary
  • Symbol
    oh
  • Name
    obstructive hydrocephalus
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:97428
    NCBI Gene: 18299
  • Alliance
Location &
Maps
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  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome Unknown
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Newborn homozygotes develop obstructive hydrocephaly followed by secondary aqueductal stenosis after 2 weeks of age. Affected mice show a severely disrupted hemispheric white matter, increased numbers of macrophages and RBCs on the ventricular surface ofthe brain, and usually die by 1 month of age.
Sequences &
Gene Models
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Other
Accession IDs
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MGD-MRK-13020
References
more
  • Summaries
    All 3
    Phenotypes 2
  • Earliest
    J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory