Axd Gene Detail

Summary

• Symbol
  Axd
• Name
  axial defects

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:88125
  NCBI Gene: 104012
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 15, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  18 phenotypes from 1 allele in 6 genetic backgrounds
  3 phenotypes from multigenic genotypes
  6 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  1 strains or lines available

Animals heterozygous for this allele may exhibit a curly tail, neural tube defects, and reduced litter size with variable penetrance depending on the genetic background.

Sequences &
Gene Models

• NCBI Gene
  104012

Other
Accession IDs

MGD-MRK-1489

References

• Summaries
  All 7

  Phenotypes 6
• Earliest
  J:10783 Essien FB, et al., Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age. Teratology. 1990 Aug;42(2):183-94
• Latest
  J:279661 Nikolopoulou E, et al., Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2. Nat Commun. 2019 Jun 6;10(1):2487