Rr695523 Other Genome Feature Detail

Summary

• Symbol
  Rr695523
• Name
  regulatory region 695523
• Synonyms
  Tbx5 RE(down)

• Feature Type
  silencer
• IDs
  MGI:8186508
• Regulates expression of
  Tbx5 (1 regulated gene)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• chr5:120029082-120053809 (GRCm39)

• Genetic Map
  Chromosome 5, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion results in Tbx5 overexpression in the heart and affects multiple heart rate related aspects.

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:360861 Bosada FM, et al., An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility. Elife. 2023 Jan 30;12

Rr695523 regulates expression of:

Feature	Feature Type	Location	Reference
Tbx5, T-box 5	protein coding gene	Chr5:119970733-120023284 (+)	J:360861