Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc
Transgene Detail

Summary

• Symbol: Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc
• Name: transgene insertion R161H, Rachel R Caspi
• MGI ID: MGI:7790611
• Synonyms: R161H
• Transgene: Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc Location: unknown
• Alliance: Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc page

Transgene origin

• Strain of Origin: B10.RIII-H2^r H2-T18^b/(71NS)SnJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains, TCR and chains were cloned from a highly uveitogenic T cell line, specific to the IRBP161180 sequence, which encodes a major pathogenic epitope for B10.RIII mice, a strain highly susceptible to experimental autoimmune uveitis (EAU). The TCR a and b sequences were placed under control of the promoter and locus control region of the human CD2 gene, and the mouse H-2K promoter, respectively. This is high expressing line R161H having 5 TCR a and 8 TCR b tandem copies of the transgene inserted into the chromosome 9. (J:296287)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:296287 Horai R, et al., Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun. 2013 Aug;44:21-33
• All: 6 reference(s)