Rr493 Other Genome Feature Detail

Summary

• Symbol
  Rr493
• Name
  regulatory region 493
• Synonyms
  Pen, Pitx1-RA5

• Feature Type
  enhancer
• IDs
  MGI:7666385
• Regulates expression of
  Pitx1 (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr13:56306831-56309000 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:268374: chr13:56260379-56262548 (mm9) chr13:56306831-56309000 (GRCm39)

• Genetic Map
  Chromosome 13, Syntenic

Strain
Comparison

• SNPs within 2kb
  163 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  3
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:268374 Kragesteen BK, et al., Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis. Nat Genet. 2018 Oct;50(10):1463-1473
• Latest
  J:317420 Rouco R, et al., Cell-specific alterations in Pitx1 regulatory landscape activation caused by the loss of a single enhancer. Nat Commun. 2021 Dec 13;12(1):7235

Rr493 regulates expression of:

Feature	Feature Type	Location	Reference
Pitx1, paired-like homeodomain transcription factor 1	protein coding gene	Chr13:55972864-55984005 (-)	J:268374