Tg(Kat6b)21Avo
Transgene Detail

Summary

• Symbol: Tg(Kat6b)21Avo
• Name: transgene insertion 21, Anne K Voss
• MGI ID: MGI:7643702
• Synonyms: Tg(Kat6b)
• Transgene: Tg(Kat6b)21Avo Location: unknown
• Alliance: Tg(Kat6b)21Avo page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Kat6b)21Avo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kat6b (MGI:1858746)	6 tandem copy of tg for overexpression

• Mutation details: The transgene is constructed from pBACe3.6 clone RP23-360F23 carrying the wild-typeKat6b allele, including 21 kb 5' and 42 kb 3' of the coding exons. All regulatory sequences necessary to recapitulate the expression pattern are included in sequences 5' of the first coding exon 2 and gene body to exon 14. Line 21 with seven copies inserted into the genome, resulting in a 5-fold increase in Kat6b expression was used for analyses. (J:348717)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:348717 Bergamasco MI, et al., The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function. Stem Cell Reports. 2024 Apr 9;19(4):469-485
• All: 1 reference(s)