Tg(CAG-DsRed,-Wap,-EGFP)14730Lmat
Transgene Detail

Summary

• Symbol: Tg(CAG-DsRed,-Wap,-EGFP)14730Lmat
• Name: transgene insertion 14730, Lydia E Matesic
• MGI ID: MGI:7593827
• Synonyms: Tg(CAG-Wap,-EGFP)14667Lmat
• Transgene: Tg(CAG-DsRed,-Wap,-EGFP)14730Lmat Location: unknown
• Alliance: Tg(CAG-DsRed,-Wap,-EGFP)14730Lmat page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The transgene construct consists of a chicken beta-actin promoter, a loxP-flanked DsRed2 reporter gene, followed by a mouse full length 2756 bp open reading frame of Wwp1 cDNA and an IRES2-EGFP construct. This transgene expresses the DsRed reporter under the control of the ubiquitous promoter. Upon cre-mediated recombination of loxP sites flanking the DsRed reporter, the mouse Wwp1 gene and the EGFP repoorter are expressed. (J:250962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:250962 Basheer WA, et al., Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis. J Mol Cell Cardiol. 2015 Nov;88:1-13
• All: 2 reference(s)