Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt
• Name: transgene insertion 17, GemPharmatech
• MGI ID: MGI:7576549
• Synonyms: Tg(Thy-APP/Thy-PSEN1/Thy-MAPT)17
• Transgene: Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt Location: unknown
• Alliance: Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt page

Transgene origin

• Strain of Origin: C57BL/6JGpt

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Tg(Thy1-APPSwe,-MAPT*P301L,-PSEN1*M146V)17Gpt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Thy1 (MGI:98747)

• Mutation details: The transgene contains the Thy1 promoter driving expression of the human APP with the Sweden mutation, MAPT with the P301L mutation, and PSEN1 with mutation M146V. (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)