Tg(Th-SNCA*)01-1Yosh
Transgene Detail

Summary

• Symbol: Tg(Th-SNCA*)01-1Yosh
• Name: transgene insertion 01-1, Makoto Yoshimoto
• MGI ID: MGI:7509800
• Synonyms: Tg(Th-SNCA*140m)01-1Yosh
• Transgene: Tg(Th-SNCA*)01-1Yosh Location: unknown
• Alliance: Tg(Th-SNCA*)01-1Yosh page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-SNCA*)01-1Yosh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  A53T point mutation

• Tg(Th-SNCA*)01-1Yosh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: The transgene construct contains the human alpha synuclein sequence with an A53T point mutation. This sequence is under control of the rat tyrosine hydroxylase (Th) promoter (9 kb of 5' flanking region of the rat Th gene). (J:125149)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:125149 Wakamatsu M, et al., Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice. Neurobiol Aging. 2008 Apr;29(4):574-85
• All: 2 reference(s)