Tg(Th-SNCA*)MI2Mgsp
Transgene Detail

Summary

• Symbol: Tg(Th-SNCA*)MI2Mgsp
• Name: transgene insertion MI2, Maria Grazia Spillantini
• MGI ID: MGI:7442149
• Synonyms: MI2
• Transgene: Tg(Th-SNCA*)MI2Mgsp Location: unknown
• Alliance: Tg(Th-SNCA*)MI2Mgsp page

Transgene origin

• Strain of Origin: C57BL/6OlaHsd-Del(6Snca)1Slab

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-SNCA*)MI2Mgsp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  transgene is truncated (1-120)

• Tg(Th-SNCA*)MI2Mgsp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: The transgenic construct is generated using truncated (1-120) human alpha-synuclein cDNA, followed by polyadenylation sequence (PolyA), and subcloned downstream of the rat Th promoter. (J:333800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:333800 Wegrzynowicz M, et al., Depopulation of dense alpha-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. Acta Neuropathol. 2019 Oct;138(4):575-595
• All: 2 reference(s)