Tg(HLA-B*3501/H2-K^b)B*3501Fal
Transgene Detail

Summary

• Symbol: Tg(HLA-B*3501/H2-K^b)B*3501Fal
• Name: transgene insertion B*3501, Francois A Lemonnier
• MGI ID: MGI:7437953
• Synonyms: HLA-B*35:01
• Transgene: Tg(HLA-B*3501/H2-K^b)B*3501Fal Location: unknown
• Alliance: Tg(HLA-B*3501/H2-K^b)B*3501Fal page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains HLA-A*02:01 promotor and the coding sequence of a chimeric molecule composed of the HLA-A*02:01 leader segment, the human beta2-m in its mature form, a 15-aa (GGGGS) x 3 linker peptide, the alpha1 alpha2 HLA class I domains, and the H-2 Db alpha3 to cytoplasmic domains. (J:205453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:205453 Boucherma R, et al., HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses. J Immunol. 2013 Jul 15;191(2):583-93
• All: 1 reference(s)