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Mirc55 Complex/Cluster/Region Detail
Summary
  • Symbol
    Mirc55
  • Name
    microRNA cluster 55, including Mir126a through Mir126b
  • Synonyms
    Mir126
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:7407146
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 2, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit edema and hemorrhaging during embryogenesis, neonatal and postnatal lethality, reduced female fecundity, decreased vascular endothelial cell integrity, and increased susceptibility to myocardial infarction.
References
more
  • Summaries
    All 18
    Phenotypes 17
  • Earliest
    J:139708 Wang S, et al., The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261-71
  • Latest
    J:330572 Guo FH, et al., Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice. Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):326-342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory