Tg(MPSV-Tcra,Tcrb)1Kshs
Transgene Detail

Summary

• Symbol: Tg(MPSV-Tcra,Tcrb)1Kshs
• Name: transgene insertion 1, Hans Schreiber
• MGI ID: MGI:7397255
• Synonyms: 1D9Tg, Tg(Mp71-1D9)
• Transgene: Tg(MPSV-Tcra,Tcrb)1Kshs Location: unknown
• Alliance: Tg(MPSV-Tcra,Tcrb)1Kshs page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MPSV-Tcra,Tcrb)1Kshs expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)	specific to UV-induced mouse tumor 8101 (MP71-1D9)
  mouse	Tcrb (MGI:98578)	specific to UV-induced mouse tumor 8101 (MP71-1D9)

• Mutation details: The viral vector expresses a high avidity T cell receptor (TCR) specific to UV-induced mouse tumor 8101 (MP71-1D9) driven by the mouse myeloproliferative sarcoma virus (MPSV) long terminal repeat (LTR) promoter. (J:331604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:331604 Leisegang M, et al., Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation. Clin Cancer Res. 2016 Jun 1;22(11):2734-43
• All: 1 reference(s)