Tg(Slc6a3-tTA)2Kftnk
Transgene Detail

Summary

• Symbol: Tg(Slc6a3-tTA)2Kftnk
• Name: transgene insertion 2, Kenji Tanaka
• MGI ID: MGI:7316790
• Synonyms: Slc6a3-tTA BAC
• Transgene: Tg(Slc6a3-tTA)2Kftnk Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(Slc6a3-tTA)2Kftnk page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Tg(Slc6a3-tTA)2Kftnk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a3 (MGI:94862)

• Mutation details: BAC clone RP24-158J12 carrying mouse Slc6a3 (also carrying Lpcat1 (short isoform) and Clptm1l) was modified with a mammalianized tTA-Sv40 polyA signal introduced into the translation initiation site. The transgenic insertion site is unknown, but qPCR suggests that two copies of the BAC were integrated in the genome. A residual FRT and loxP site remain in the 3' end of the modified Slc6a3 segment. Founder line 2 carries higher transgene penetrance in dopamine neurons. (J:326690)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:326690 Amo R, et al., A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning. Nat Neurosci. 2022 Jul 7
• All: 1 reference(s)