Tg(Igkv3-5*-MYC)DLoxP4Plbe
Transgene Detail

Summary

• Symbol: Tg(Igkv3-5*-MYC)DLoxP4Plbe
• Name: transgene insertion DLoxP4, P Leif Bergsagel
• MGI ID: MGI:6856591
• Synonyms: Tg(Igkv3-5*DLoxP-MYC)4Plbe, VkMYCDLoxP, Vk*MYCDLoxP
• Transgene: Tg(Igkv3-5*-MYC)DLoxP4Plbe Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tg(Igkv3-5*-MYC)DLoxP4Plbe page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igkv3-5*-MYC)DLoxP4Plbe involves 1 genes/genome features (Gm41210) View all
• Tg(Igkv3-5*-MYC)DLoxP4Plbe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. This vector lacks the loxP site found in Tg(Igkv3-5*-MYC)24Plbe. Line 4 inserted at chr14:74838906-74848613 (mm39) with deletion of intervening region. (J:94077, J:131912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 3 reference(s)