Tg(Gsta1-NFE2L2/luc)M2Tiw
Transgene Detail

Summary

• Symbol: Tg(Gsta1-NFE2L2/luc)M2Tiw
• Name: transgene insertion M2, Takao Iwawaki
• MGI ID: MGI:6791300
• Synonyms: OKD48, OKD48^Luc, Tg(3xARE/TK-NRF2/luc)M2Tiw
• Transgene: Tg(Gsta1-NFE2L2/luc)M2Tiw Location: unknown
• Alliance: Tg(Gsta1-NFE2L2/luc)M2Tiw page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: antioxidant
• Mutation: Insertion
• Tg(Gsta1-NFE2L2/luc)M2Tiw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFE2L2 (4780)

  Nfe2l2

  (MGI:108420)

• Tg(Gsta1-NFE2L2/luc)M2Tiw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gsta1 (MGI:1095417)

• Mutation details: The transgene contains three copies of the antioxidant responsive element from the mouse Gsta1 promoter fused to a basal TK promoter driving inducible expression of human NRF2 (amino acids 1-433) with a FLAG-tagged luciferase reporter gene. Line M2 was generated. (J:257947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:257947 Oikawa D, et al., A transgenic mouse model for monitoring oxidative stress. Sci Rep. 2012;2:229
• All: 4 reference(s)