Tg(Ube3a)5Mpan
Transgene Detail

Summary

• Symbol: Tg(Ube3a)5Mpan
• Name: transgene insertion 5, Matthew Anderson
• MGI ID: MGI:6754127
• Synonyms: Ube3a-2x (untagged), Ube3a OFF#5
• Transgene: Tg(Ube3a)5Mpan Location: unknown
• Alliance: Tg(Ube3a)5Mpan page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ube3a)5Mpan expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ube3a (MGI:105098)	loxP sites flanking exons 3-5

• Mutation details: The transgenic construct contains the entire ubiquitin protein ligase E3A (Ube3a) gene; it is designed to have a loxp sites flanking exons 3-5. A single FRT site remains just downstream of exon 5 (a remnant of the FRT-flanked zeomycin resistance cassette that was removed by a FLP-expressing plasmid during the BAC recombineering). (J:244070)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:244070 Krishnan V, et al., Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Nature. 2017 Mar 23;543(7646):507-512
• All: 2 reference(s)