Tg(Thy1-Usp14*C114A)5-40Swi
Transgene Detail

Summary

• Symbol: Tg(Thy1-Usp14*C114A)5-40Swi
• Name: transgene insertion 5-40, Scott Wilson
• MGI ID: MGI:6715064
• Synonyms: TgUsp14CA
• Transgene: Tg(Thy1-Usp14*C114A)5-40Swi Location: unknown
• Alliance: Tg(Thy1-Usp14*C114A)5-40Swi page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-Usp14*C114A)5-40Swi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Usp14 (MGI:1928898)	Usp14*C114A

• Mutation details: The transgenic construct contains a modified full length mouse Usp14 cDNA (including the Usp14 Kozak sequence) under the control of the pan-neuronal Thy1 (Thy1.2) promoter. The Usp14 sequence is modified to change the active site cysteine to an alanine (C114A) at position 114. (J:306115)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:306115 Vaden JH, et al., Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction. Mol Neurodegener. 2015 Jan 10;10:3
• All: 1 reference(s)