Tg(Cebpa-CD4*)1Afrdm
Transgene Detail

Summary

• Symbol: Tg(Cebpa-CD4*)1Afrdm
• Name: transgene insertion 1, Alan Friedman
• MGI ID: MGI:6487887
• Synonyms: Cebpa-hCD4
• Transgene: Tg(Cebpa-CD4*)1Afrdm Location: unknown
• Alliance: Tg(Cebpa-CD4*)1Afrdm page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cebpa-CD4*)1Afrdm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD4 (920)

  Cd4	(MGI:88335)

  cytoplasmic truncation of human CD4

• Mutation details: The transgene is designed with the hematopoietic-specific CCAAT/enhancer binding protein (C/EBP), alpha + 37 kb enhancer directing expression of a cytoplasmicaly truncated human CD4 antigen cDNA followed by an avian beta-globin insulator. (J:222300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:222300 Guo H, et al., The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells. J Leukoc Biol. 2014 Sep;96(3):419-26
• All: 3 reference(s)