Tg(Cd3d-Insr*)1Mcin
Transgene Detail
|
Symbol: |
Tg(Cd3d-Insr*)1Mcin |
Name: |
transgene insertion 1, Marcia McInerney |
MGI ID: |
MGI:6478197 |
Synonyms: |
CD3-3FLAG-mIR/MFM |
Transgene: |
Tg(Cd3d-Insr*)1Mcin Location: unknown
|
Alliance: |
Tg(Cd3d-Insr*)1Mcin page
|
|
|
Transgene Type: |
|
Transgenic (Epitope tag, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Cd3d-Insr*)1Mcin expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Insr (MGI:96575) |
3XFLAG tagged |
|
|
|
Tg(Cd3d-Insr*)1Mcin expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cd3d (MGI:88331) |
|
|
|
|
Mutation details: The transgene insert encodes a full-length mouse insulin receptor protein cDNA containing an N-terminal 3xFLAG (DYKDDDDK) tagged alpha-subunit and full length beta-subunit as seen in the native mouse Insr gene. The endogenous signal peptide coding sequence was deleted and replaced with a pre-protrypsin (PPT) signal peptide. Thetransgene is placed downstream of the mouse Cd3d enhancer and promoter construct to elicit T-lymphocyte directed transgene over-expression. A human growth hormone (hGH) poly A signal enhances mRNA stability
(J:303894)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:303894 Nandedkar-Kulkarni N, et al., Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice. J Immunol. 2021 Apr 1;206(7):1443-1453 |
All: |
3 reference(s) |
|