Tg(CHMP2B*)153Aisa
Transgene Detail

Summary

• Symbol: Tg(CHMP2B*)153Aisa
• Name: transgene insertion 153, Adrian Isaacs
• MGI ID: MGI:6473100
• Synonyms: CHMP2B^intron5, Tg(CHMP2B-Intron5)153Isa
• Transgene: Tg(CHMP2B*)153Aisa Location: unknown
• Alliance: Tg(CHMP2B*)153Aisa page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CHMP2B*)153Aisa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHMP2B (25978)

  Chmp2b

  (MGI:1916192)

  Intron 5 mutation

• Mutation details: The transgene contains the human gene with a stop codon inserted into exon 5 resulting in the loss of the last 36 amino acids. Lines Tg153 and Tg156 were generated. (J:221848)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:221848 Ghazi-Noori S, et al., Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012 Mar;135(Pt 3):819-32
• All: 6 reference(s)